Please use this identifier to cite or link to this item:
http://repositorio.ufla.br/jspui/handle/1/41830| Title: | Conformational analysis and intramolecular interactions in aminofluorobenzoic acids |
| Keywords: | Hydrogen Carboxyls Energy Noncovalent interactions Molecular structure |
| Issue Date: | 29-Jan-2013 |
| Publisher: | American Chemical Society (ACS) |
| Citation: | SILLA, J. M. et al. Conformational analysis and intramolecular interactions in aminofluorobenzoic acids. The Journal of Physical Chemistry A, [S.l.], v. 117, n. 7, p. 1659-1664, Jan. 2013. DOI: 10.1021/jp311791g. |
| Abstract: | Some aminofluorobenzoic acids were studied to evaluate the power of the F···HO hydrogen bond and other interactions as driving forces of the conformational isomerism of these compounds. Despite the occurrence of this hydrogen bond in the 2-fluorinated derivatives, as well as attractive O/F nonbonding interactions and NH···O═C hydrogen bond, the O/O repulsion dictates the orientation of the carboxyl group. Unlike 2-fluorophenol, which is reported to not experience a F···HO hydrogen bond, 2-fluorobenzoic acid derivatives were calculated to exhibit such interaction, but it could not be monitored experimentally by means of F/H(O) coupling constant, because of the low solubility of these compounds in nonpolar solvents, the acidity of the carboxyl hydrogen, the small population of some conformers capable of exhibiting hydrogen bond, and the solute self-association in solution, which make their conformational equilibrium different from that in gas phase. |
| URI: | https://pubs.acs.org/doi/10.1021/jp311791g http://repositorio.ufla.br/jspui/handle/1/41830 |
| Appears in Collections: | DQI - Artigos publicados em periódicos |
Files in This Item:
There are no files associated with this item.
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.