Please use this identifier to cite or link to this item: http://repositorio.ufla.br/jspui/handle/1/43566
metadata.artigo.dc.title: Myocarditis is rare in COVID-19 autopsies: Cardiovascular findings across 277 post-mortem examinations
metadata.artigo.dc.creator: Halushka, Marc K.
Heide, Richard S. Vander
metadata.artigo.dc.subject: COVID-19
Coronavirus
SARS-CoV-2
Myocarditis
Heart inflammation
Miocardite
Inflamação do coração
metadata.artigo.dc.publisher: Elsevier
metadata.artigo.dc.date.issued: 2020
metadata.artigo.dc.identifier.citation: HALUSHKA, M. K.; HEIDE, R. S. V. Myocarditis is rare in COVID-19 autopsies: Cardiovascular findings across 277 post-mortem examinations. Cardiovascular Pathology, Philadelphia, 107300, 2020. DOI: https://doi.org/10.1016/j.carpath.2020.107300.
metadata.artigo.dc.description.abstract: The COVID-19 pandemic, the result of SARS-CoV-2, is a major cause of worldwide mortality with a significant cardiovascular component. While a number of different cardiovascular histopathologies have been reported at post-mortem examination, their incidence is unknown, due to limited numbers of cases in any given study. A literature review was performed identifying 277 autopsied hearts across 22 separate publications of COVID-19 positive patients. The median age of the autopsy cohort was 74.5 and 97.6% had one or more comorbidities. Initial review of the data indicate that myocarditis was present in 20 hearts (7.2%); however, closer examination of additional reported information revealed that most cases were likely not functionally significant and the true prevalence of myocarditis is likely much lower (<2%). At least one acute, potentially COVID-19 related cardiovascular histopathologic finding, such as macro or microvascular thrombi, inflammation, or intraluminal megakaryocytes, was reported in 47.8% of cases. Significant differences in reporting of histopathologic findings occurred between studies indicating strong biases in observations and the need for more consistency in reporting. In conclusion, across 277 cases, COVID-19 related cardiac histopathological findings, are common, while myocarditis is rare.
metadata.artigo.dc.identifier.uri: https://www.sciencedirect.com/science/article/abs/pii/S1054880720301046#!
http://repositorio.ufla.br/jspui/handle/1/43566
metadata.artigo.dc.language: en_US
Appears in Collections:FCS - Artigos sobre Coronavirus Disease 2019 (COVID-19)

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