1. RI UFLA
  2. Faculdade de Ciências da Saúde - FCS
  3. FCS - Artigos sobre Coronavirus Disease 2019 (COVID-19)
Use este identificador para citar ou linkar para este item: http://repositorio.ufla.br/jspui/handle/1/43574
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dc.creatorZeberg, Hugo-
dc.creatorPääbo, Svante-
dc.date.accessioned2020-10-27T17:53:09Z-
dc.date.available2020-10-27T17:53:09Z-
dc.date.issued2020-
dc.identifier.citationZEBERG , H.; PÄÄBO, S. The major genetic risk factor for severe COVID-19 is inherited from Neanderthals. Nature, [S.l.], 2020. Online ahead of print.pt_BR
dc.identifier.urihttps://www.nature.com/articles/s41586-020-2818-3pt_BR
dc.identifier.urihttp://repositorio.ufla.br/jspui/handle/1/43574-
dc.description.abstractA recent genetic association study1 identified a gene cluster on chromosome 3 as a risk locus for respiratory failure after infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). A separate study (COVID-19 Host Genetics Initiative)2 comprising 3,199 hospitalized patients with coronavirus disease 2019 (COVID-19) and control individuals showed that this cluster is the major genetic risk factor for severe symptoms after SARS-CoV-2 infection and hospitalization. Here we show that the risk is conferred by a genomic segment of around 50 kilobases in size that is inherited from Neanderthals and is carried by around 50% of people in south Asia and around 16% of people in Europe.pt_BR
dc.languageen_USpt_BR
dc.publisherNature Publishing Grouppt_BR
dc.rightsrestrictAccesspt_BR
dc.sourceNaturept_BR
dc.subjectCOVID-19pt_BR
dc.subjectSevere Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2)pt_BR
dc.subjectGenetic predispositionpt_BR
dc.subjectChromosome 3pt_BR
dc.titleThe major genetic risk factor for severe COVID-19 is inherited from Neanderthalspt_BR
dc.typeArtigopt_BR
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