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http://repositorio.ufla.br/jspui/handle/1/43574| Título : | The major genetic risk factor for severe COVID-19 is inherited from Neanderthals |
| Autor: | Zeberg, Hugo Pääbo, Svante |
| Palavras-chave: | COVID-19 Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Genetic predisposition Chromosome 3 |
| Publicador: | Nature Publishing Group |
| Data da publicação: | 2020 |
| Referência: | ZEBERG , H.; PÄÄBO, S. The major genetic risk factor for severe COVID-19 is inherited from Neanderthals. Nature, [S.l.], 2020. Online ahead of print. |
| Abstract: | A recent genetic association study1 identified a gene cluster on chromosome 3 as a risk locus for respiratory failure after infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). A separate study (COVID-19 Host Genetics Initiative)2 comprising 3,199 hospitalized patients with coronavirus disease 2019 (COVID-19) and control individuals showed that this cluster is the major genetic risk factor for severe symptoms after SARS-CoV-2 infection and hospitalization. Here we show that the risk is conferred by a genomic segment of around 50 kilobases in size that is inherited from Neanderthals and is carried by around 50% of people in south Asia and around 16% of people in Europe. |
| URI: | https://www.nature.com/articles/s41586-020-2818-3 http://repositorio.ufla.br/jspui/handle/1/43574 |
| Idioma: | en_US |
| Aparece nas coleções: | FCS - Artigos sobre Coronavirus Disease 2019 (COVID-19) |
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