Please use this identifier to cite or link to this item: http://repositorio.ufla.br/jspui/handle/1/45420
metadata.artigo.dc.title: Racial differences and an increased systemic inflammatory response are seen in patients with COVID-19 and ischemic stroke
metadata.artigo.dc.creator: Lin, Chen
Arevalo, Yurany A.
Nanavati, Hely D.
Lin, Diana M.
metadata.artigo.dc.subject: Stroke
COVID-19
Coronavirus immune response
Neutrophil-to-lymphocyte ratio
Racial disparities
metadata.artigo.dc.publisher: Elsevier
metadata.artigo.dc.date.issued: Oct-2020
metadata.artigo.dc.identifier.citation: LIN, C. et al. Racial differences and an increased systemic inflammatory response are seen in patients with COVID-19 and ischemic stroke. Brain, Behavior, & Immunity - Health, [S.l.], v. 8, Oct. 2020.
metadata.artigo.dc.description.abstract: Objective To describe the difference in clinical presentation, including race, of ischemic stroke between patients with and without novel coronavirus disease 2019 (COVID-19), and the association of inflammatory response with stroke severity. Methods This is a retrospective, observational, cross-sectional study of patients (n ​= ​60) admitted with ischemic stroke between late March and early May 2020. All patients were tested for COVID-19 during admission. Demographic, clinical, and laboratory data was collected through electronic medical record review. Descriptive statistics was performed to observe the differences between stroke patients with and without COVID-19 Results 60 hospitalized patients with acute ischemic stroke were included in the analysis. Nine were positive for COVID-19. African-Americans comprised of 55.6% of those that had COVID-19 and stroke and 37.7% of those with only stroke. Stroke patients with COVID-19 had a significantly higher NIHSS [18.4 (8.8)] and neutrophil-to-lymphocyte ratio (NLR) [7.3 (4.2) vs 3.8 (2.8); P ​= ​0.0137] than those without. Those with COVID-19 also had a significantly higher mortality rate (44.4% vs. 7.6%; p ​< ​0.001). Conclusion We observed a cohort of patients, including a large proportion of African-Americans, who developed ischemic stroke with or without COVID-19. An exaggerated inflammatory response, as indicated by NLR, likely plays a role in stroke severity among COVID-19 patients that concurrently develop ischemic stroke.
metadata.artigo.dc.identifier.uri: https://www.sciencedirect.com/science/article/pii/S2666354620301022
http://repositorio.ufla.br/jspui/handle/1/45420
metadata.artigo.dc.language: en_US
Appears in Collections:FCS - Artigos sobre Coronavirus Disease 2019 (COVID-19)

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