Use este identificador para citar ou linkar para este item: http://repositorio.ufla.br/jspui/handle/1/45421
Título : The incidence of COVID-19 in patients with metabolic syndrome and non-alcoholic steatohepatitis: a population-based study
Autor: Ghoneim, Sara
Butt, Muhammad Umer
Hamid, Osama
Shah, Aun
Asaad, Imad
Palavras-chave: COVID-19
Non-alcoholic steatohepatitis
Metabolic syndrome
Obesity
Diabetes mellitus
African americans
Publicador: Elsevier
Data da publicação: Dez-2020
Referência: GHONEIM, S. et al. The incidence of COVID-19 in patients with metabolic syndrome and non-alcoholic steatohepatitis: a population-based study. Metabolism Open, [S.l.], v. 8, Dec. 2020.
Abstract: Background The novel coronavirus disease (COVID-19) emerged from China in 2019 and rapidly spread worldwide. Patients with metabolic comorbid conditions are more susceptible to infection by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Metabolic syndrome is a constellation of interlinked metabolic risk factors that predispose patients to increased risk of complications. Non-alcoholic fatty liver disease (NAFLD) is the hepatic manifestation of metabolic syndrome and non-alcoholic steatohepatitis (NASH) is the aggressive form of NAFLD. Objective The aim of this study is to determine the relationship between metabolic syndrome components and the risk of COVID-19. Methods We reviewed data from a large commercial database (Explorys IBM) that aggregates electronic health records from 26 large nationwide healthcare systems. Using systemized nomenclature of clinical medical terms (SNOMED-CT), we identified adults with the diagnosis of metabolic syndrome and its individual components from 1999 to 2019. We included patients with the diagnosis of COVID-19 from December 2019 to May 2020. Comorbidities known to be associated with COVID-19 and metabolic syndrome such as obesity, diabetes mellitus, dyslipidemia, smoking, male gender, African American, and hypertension were collected. Univariable and multivariable analyses were performed to investigate whether metabolic syndrome or its individual components are independently associated with the risk of COVID-19. Results Out of 61.4 million active adult patients in the database, 8885 (0.01%) had documented COVID-19. The cumulative incidence of COVID-19 was higher if metabolic syndrome was the primary diagnosis (0.10% vs 0.01%, OR 7.00 [6.11–8.01]). The adjusted odds (aOR) of having COVID-19 was higher in patients if they were African Americans (aOR 7.45 [7.14–7.77]), hypertensive (aOR 2.53 [2.40–2.68]), obese (aOR 2.20 [2.10–2.32]), diabetic (aOR 1.41 [1.33–1.48]), hyperlipidemic (aOR 1.70 [1.56–1.74]), or diagnosed with NASH (aOR 4.93 [4.06–6.00]). There was a slight decrease in the adjusted odds of having COVID-19 in males as compared to females (aOR 0.88 [0.84–0.92]). Conclusion The incidence of COVID-19 in patients with metabolic syndrome is high. Among all comorbid metabolic conditions, NASH had the strongest association with COVID-19.
URI: https://www.sciencedirect.com/science/article/pii/S2589936820300372
http://repositorio.ufla.br/jspui/handle/1/45421
Idioma: en_US
Aparece nas coleções:FCS - Artigos sobre Coronavirus Disease 2019 (COVID-19)

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