Please use this identifier to cite or link to this item: http://repositorio.ufla.br/jspui/handle/1/48833
Title: Hybrid materials based on magnetic iron oxides with benzothiazole derivatives: a plausible potential spectroscopy probe
Keywords: Hybrid material
Feroxyhyte
Benzothiazole
DFT method
Molecular docking
Spectroscopy probe
Density functional theory (DFT)
Issue Date: 12-Apr-2021
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
Citation: CORREA, S. et al. Hybrid materials based on magnetic iron oxides with benzothiazole derivatives: a plausible potential spectroscopy probe. International Journal of Molecular Sciences, [S.l.], v. 22, n. 8, p. 3980-3992, Apr. 2021. DOI: 10.3390/ijms22083980.
Abstract: Rare diseases affect a small part of the population, and the most affected are children. Because of the low availability of patients for testing, the pharmaceutical industry cannot develop drugs for the diagnosis of many of these orphan diseases. In this sense, the use of benzothiazole compounds that are highly selective and can act as spectroscopy probes, especially the compound 2-(40-aminophenyl)benzothiazole (ABT), has been highlighted. This article reports the design of potential contrast agents based on ABT and iron to develop a new material with an efficient mechanism to raise the relaxation rate, facilitating diagnosis. The ABT/δ-FeOOH hybrid material was prepared by grafting (N-(4’-aminophenyl) benzothiazole-2-bromoacetamide) on the surface of the iron oxyhydroxide particles. FTIR spectra confirmed the material formations of the hybrid material ABT/δ-FeOOH. SEM analysis checked the covering of nanoflakes’ surfaces in relation to the morphology of the samples. The theoretical calculations test a better binding mode of compound with iron oxyhydroxide. Theoretical findings show the radical capture mechanism in the stabilization of this new material. In this context, Fe3+ ions are an electron acceptor from the organic phase.
URI: http://repositorio.ufla.br/jspui/handle/1/48833
Appears in Collections:DQI - Artigos publicados em periódicos



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