Please use this identifier to cite or link to this item: http://repositorio.ufla.br/jspui/handle/1/50867
Title: Voluntary physical activity mitigates alveolar bone loss in mice with ligature-induced experimental periodontitis
Keywords: Inflammation
Voluntary physical activity
Voluntary exercise
Periodontitis
Free running wheel
Locomotor behavior
Periodontite
Atividade física voluntária
Comportamento locomotor
Issue Date: Aug-2022
Publisher: Elsevier
Citation: BERTOLINI, N. O. et al. Voluntary physical activity mitigates alveolar bone loss in mice with ligature-induced experimental periodontitis. Archives of Oral Biology, [S.I.], v. 140, 105451, Aug. 2022. DOI: https://doi.org/10.1016/j.archoralbio.2022.105451.
Abstract: Objective: To investigate the effect of voluntary physical activity (VPA) on inflammatory profile and the progression of experimental periodontal disease (PD) in mice. Methods: Male C57BL/6 mice were randomly distributed into Control; VPA; PD and PD/VPA groups. We registered VPA (total volume of revolutions) and average speed (revolutions/minute) in a free running wheel for 30 days. On the 15th day, animals from the PD and PD/VPA groups received ligatures on the upper second molars bilaterally. On the 30th day animals were euthanized, and PD progression was assessed by measuring alveolar bone loss (ABL - the linear distance between the cemento-enamel junction and the alveolar bone crest on the teeth buccal surface). Gene expression of RANKL (kappa nuclear factor B receptor) OPG (osteoprotegerin), IL-1β (interleukin 1 beta), IL-6 (interleukin 6) and TNF-α (tumor necrosis factor alpha) were evaluated by real-time PCR (quantitative Polymerase Chain Reaction - relative gene expression). Results: The total volume of physical activity and the activity speed decreased along the seven days after ligatureplacement (p < 0.05), returning to a similar pattern in relation to VPA group. Ligature placement produced significant bone resorption, and increased RANKL, IL-1β, IL-6 and TNF-α expression. VPA reduced ABL (p < 0,05) and the expression of TNF-α and IL-1β, whereas increased OPG expression. Conclusion: Animals induced to PD with access to the VPA wheel presented both lower gingival inflammation and less alveolar bone resorption in comparison to animals without access to the wheel.
URI: https://doi.org/10.1016/j.archoralbio.2022.105451
http://repositorio.ufla.br/jspui/handle/1/50867
Appears in Collections:DEF - Artigos publicados em periódicos
DME - Artigos publicados em periódicos
DMV - Artigos publicados em periódicos

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