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http://repositorio.ufla.br/jspui/handle/1/56695| Title: | Inhibition of α-Glycosidase by Lippia dulcis Trevir. (Verbenaceae) preparations, quantification of verbascoside, and study of its molecular docking |
| Keywords: | Medicinal plant Capim doce Hypoglycemic agent Glucosidase inhibitors Phenylethanoid glycoside |
| Issue Date: | Feb-2023 |
| Publisher: | Wiley |
| Citation: | RUAS, N. R. et al. Inhibition of α-Glycosidase by Lippia dulcis Trevir. (Verbenaceae) preparations, quantification of verbascoside, and study of its molecular docking. Chemistry & Biodiversity, [S.l.], v. 20, n. 2, Feb. 2023. |
| Abstract: | This studyaimedto quantifyverbascoside(VEB),performmoleculardockingstudiesof VEB with theα-glucosidase(GL) ofBacillusstearothermophilus,and evaluatethe inhibitionof the enzymebyL. dulcispreparations.The substrateconcentrationand presenceof reducedglutathionewere evaluatedfor their effecton thein vitroinhibitionof the GL enzyme.Assayswere also performedin the presenceand absenceofsimulatedgastricfluid. The antidiabeticfractions2 and 3 were the most inhibitedGL, but their activityweresignificantlydecreasedin the presenceof gastricfluid. Chromatographicanalysesconfirmedthe predominantpresenceof VEB in the samples.The sampleshad VEB concentrationsbetween49.9 and 243.5 mg/g.Simulationof the moleculardockingof VEB were consistentwith its GL-inhibitoryactivity.It can concludethat the crudeethanolextractand fractionsshow inhibitoryactivityagainstthe GL enzyme. |
| URI: | https://onlinelibrary.wiley.com/doi/10.1002/cbdv.202200760 http://repositorio.ufla.br/jspui/handle/1/56695 |
| Appears in Collections: | DAG - Artigos publicados em periódicos |
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