Please use this identifier to cite or link to this item:
Full metadata record
DC FieldValueLanguage
dc.creatorPereira, Marina Apocalypse Nogueira-
dc.creatorSilva Junior, Ediu Carlos da-
dc.creatorSilva, Istefani Luciene Dayse da-
dc.creatorCarvalho, Bárbara Andrade de-
dc.creatorFerreira, Enio-
dc.creatorAndrade, Eric Francelino-
dc.creatorGuilherme, Luiz Roberto Guimarães-
dc.creatorPereira, Luciano José-
dc.identifier.citationPEREIRA, M. A. N. et al. Antitumor effect of selenium-rich Brazil nuts and selenomethionine dietary supplementation on pre-existing 4T1 mammary tumor growth in mice. Plos One, [S.l.], v. 18, n. 1, 2023.pt_BR
dc.description.abstractSelenium (Se) is an essential micronutrient known to play an important role in the antioxidant system that can potentially influence tumor growth. We aimed to investigate the effects of dietary Se supplementation after detection of 4T1 mammary tumor growth in BALB/c mice. Thirty female mice received subcutaneous inoculation of 4T1 cells. After five days, all animals presenting palpable tumors were randomly assigned to three groups: a control group (Se-control) receiving a diet with adequate Se (0.15 mg/kg) and two other groups that received Se-supplemented diets (1.4 mg/kg of total Se) with either Brazilian nuts (Se-Nuts) or selenomethionine (SeMet). Data were assessed by either One or Two-way ANOVA followed by Tukey’s HSD or Bonferroni’s post hoc tests, respectively. Both Se-supplemented diets reduced tumor volume from the thirteenth day of feeding compared with the Se-adequate (control) diet (p < 0.05). The SeMet group presented a higher Se blood concentration (p < 0.05) than the Se-control group, with the Se-Nuts group presenting intermediate values. Selenoprotein P gene expression in the liver was higher in the Se-Nuts group than in the Se-control group (p < 0.05), while the SeMet group presented intermediate expression. Dietary Se supplementation, starting after detection of 4T1 palpable lesions, reduced tumor volume in mice.pt_BR
dc.rightsacesso abertopt_BR
dc.rightsAttribution 4.0 International*
dc.sourcePlos Onept_BR
dc.subjectSe supplementationpt_BR
dc.subject4T1 mammary tumorpt_BR
dc.subjectBALB/c micept_BR
dc.titleAntitumor effect of selenium-rich Brazil nuts and selenomethionine dietary supplementation on pre-existing 4T1 mammary tumor growth in micept_BR
Appears in Collections:DMV - Artigos publicados em periódicos

This item is licensed under a Creative Commons License Creative Commons