Use este identificador para citar ou linkar para este item: http://repositorio.ufla.br/jspui/handle/1/57485
Título: P1G10, the proteolytic fraction from vasconcellea cundinamarcensis, stimulates tissue repair after acute exposure to ultraviolet B radiation
Palavras-chave: Antioxidant
Anti-inflammatory
C. candamarcensis
Erythema
Proteolytic
Papain
Ultraviolet
Healing
Data do documento: 2019
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
Citação: FREITAS, K. M. et al. P1G10, the proteolytic fraction from vasconcellea cundinamarcensis, stimulates tissue repair after acute exposure to ultraviolet B radiation. International Journal of Molecular Sciences, [S.l.], v. 20, n. 18, 2019.
Resumo: Background: P1G10 is a cysteine proteolytic fraction from Vasconcellea cundinamarcensis latex, obtained by chromatographic separation on Sephadex-G10 and ultrafiltration. This fraction enhances healing in different models of skin lesions, and displays a protective/healing effect against gastric ulcers, where it was suggested an antioxidant role. Methods: We evaluated here the effect of topical treatment with P1G10, in mice lesions induced by UVB. Results: After single exposure to 2.4 J cm−2 UVB, P1G10 reduced erythema, increased cellularity of hypodermis, enhanced MPO activity and IL1β, and inhibited COX2 levels. These results point to an anti-inflammatory effect by P1G10. This fraction displayed antioxidant activity by reversing the depletion of glutathione (GSH), glutathione peroxidase (GSH-Px), superoxide dismutase (SOD) and reducing the catalase activity increased by UVB. These changes may be related to a reduction in MDA observed in groups treated with P1G10. P1G10 also inhibited MMP-9, caspase-3 and pkat while increasing p53 levels.
URI: https://www.mdpi.com/1422-0067/20/18/4373
http://repositorio.ufla.br/jspui/handle/1/57485
Aparece nas coleções:DMV - Artigos publicados em periódicos

Arquivos associados a este item:
Não existem arquivos associados a este item.


Os itens no repositório estão protegidos por copyright, com todos os direitos reservados, salvo quando é indicado o contrário.