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Título: | Simulação do efeito antinociceptivo de detomidina em cavalos |
Título(s) alternativo(s): | Detomidine anti-society effects simulation study in horses |
Palavras-chave: | Analises PK/PD Analgésicos Determinação de doses PK / PD analyzes Analgesics Determination of doses |
Data do documento: | 2019 |
Editor: | Centro Científico Conhecer |
Citação: | FONTANELA, M. A. C.; FERRANTE, M. Simulação do efeito antinociceptivo de detomidina em cavalos. Enciclopédia Biosfera, Goiânia, v. 16, n. 29, p. 827-834, 2019. |
Resumo: | This study aimed to simulate the antinociceptive effect of detomidine IV and IM in horses at a dose of 80 ug / kg. The pharmacokinetic / pharmacodynamic analysis was performed using the equation. Pharmacokinetic and pharmacodynamic data were those corresponding to the study at doses of 30æg / kg. The antinociceptive effect was considered from the nociceptive threshold changes. Finally, the antinociceptive effect was determined from the high doses of detomidine (80 ug / kg) from the plasma concentrations by means of a simulation. The simulated antinociceptive effect from plasma concentrations corresponding to doses of 80 ug / kg was 90%, 80% and 40% up to 120, 180 and 240 minutes for the IM route and was 90%, 80% and 60% up to 120, 180 and 240 minutes for the IV route, respectively. Elevated doses of detomidine determine superior and more gilding effects at doses of 30æg / kg by respective routes of administration. However, in vivo studies complete at these high doses are required to verify adverse effects. |
URI: | http://repositorio.ufla.br/jspui/handle/1/57613 |
Aparece nas coleções: | DMV - Artigos publicados em periódicos |
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