Please use this identifier to cite or link to this item: http://repositorio.ufla.br/jspui/handle/1/57826
Title: Protective effect of β-glucan and glutamine on intestinal and immunological damage in mice induced by cytarabine (Ara-C)
Other Titles: Efeito protetor do β-glucano e glutamina em lesões intestinais e imunológicas induzidas por ciratabina (Ara-C) em camundongos
Keywords: β-glucan
Glutamine
Intestine
Immunology
Mice
Cytarabine
Ara-C
Chemotherapy
Yeast
Intestinal health
Immunomodulators
β-glucano
Glutamina
Intestino
Imunologia
Ciratabina
Camundongo
Quimioterapia
Levedura
Saúde intestinal
Imunomoduladores
Issue Date: Sep-2017
Publisher: Colégio Brasileiro de Patologia Animal - CBPA. Empresa Brasileira de Pesquisa Agropecuária (EMBRAPA)
Citation: PORSANI, M. Y. B. et al. Protective effect of β-glucan and glutamine on intestinal and immunological damage in mice induced by cytarabine (Ara-C). Pesquisa Veterinária Brasileira, Rio de Janeiro, v. 37, n. 9, Sept. 2017.
Abstract: Recently, glutamine and β-glucan have been demonstrated to play an important role in modulation of the immune system and in promoting intestinal health benefits. The aim of this study was to investigate the effect of this intervention on inflammatory responses and intestinal health in mice orally pretreated with soluble Saccharomyces cerevisiae derived 1,3/1,6-β-glucan (80mg/kg) with or without glutamine (150mg/kg) and then challenged with cytarabine (Ara-C) (15mg/kg). Improvements in villi and crypts were not observed in the β-glucan group. The intestinal morphometry in the glutamine group showed the best results. β-glucan in combination with glutamine presented the highest values of IL-1β and IL-10 and lowest values for leukocytes and INF-γ. Based on these results, combined β-glucan and glutamine pretreatment reduced intestinal inflammation and improved the immune response after Ara-C challenge.
URI: http://repositorio.ufla.br/jspui/handle/1/57826
Appears in Collections:DMV - Artigos publicados em periódicos

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