Modelagem farmacocinética e simulação de protocolos terapêuticos da Ivermectina a 1% em bovinos Tabapuã e GIR

Abstract

Ivermectin (IVM) is one of the most used antiparasitics worldwide, and has already established itself, in cattle farming, as the drug of choice for treating helminths and ticks (Ballweber & Baeten, 2012; Gotardo et al., 2020). Most of the IVM administered to cattle is excreted unchanged, and eliminated mainly in feces (Canga et al., 2009). This is an important route for introducing waste into the environment, producing negative impacts on living organisms and driving the selection of resistant parasites (Klatte et al., 2017). In view of the above, the objectives of this work were: 1 - to prepare a literature review regarding the use of IVM in Veterinary Medicine, and on the applications of pharmacometrics in animal health; 2 - evaluate the pharmacokinetic profile of a 1% IVM formulation, in Tabapuã cattle (Bos taurus indicus), and simulate different protocols for the treatment of endo and ectoparasites; 3 - evaluate the pharmacokinetic profile of a 1% IVM formulation in Gir calves and heifers (Bos taurus indicus), and simulate protocols for the treatment of nematodes.