Inhibition of α-Glycosidase by Lippia dulcis Trevir. (Verbenaceae) preparations, quantification of verbascoside, and study of its molecular docking

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dc.creatorRuas, Natalia Ritter
dc.creatorPereira, Aline Carvalho
dc.creatorPereira, Luciana Lopes Silva
dc.creatorGermano, Carolina Mesquita
dc.creatorCunha, Elaine Fontes Ferreira da
dc.creatorCarvalho, Alexandre Alves de
dc.creatorLameira, Osmar Alves
dc.creatorPinto, José Eduardo Brasil Pereira
dc.creatorBertolucci, Suzan Kelly Vilela
dc.date.accessioned2023-04-24T15:39:30Z
dc.date.available2023-04-24T15:39:30Z
dc.date.issued2023-02
dc.description.abstractThis studyaimedto quantifyverbascoside(VEB),performmoleculardockingstudiesof VEB with theα-glucosidase(GL) ofBacillusstearothermophilus,and evaluatethe inhibitionof the enzymebyL. dulcispreparations.The substrateconcentrationand presenceof reducedglutathionewere evaluatedfor their effecton thein vitroinhibitionof the GL enzyme.Assayswere also performedin the presenceand absenceofsimulatedgastricfluid. The antidiabeticfractions2 and 3 were the most inhibitedGL, but their activityweresignificantlydecreasedin the presenceof gastricfluid. Chromatographicanalysesconfirmedthe predominantpresenceof VEB in the samples.The sampleshad VEB concentrationsbetween49.9 and 243.5 mg/g.Simulationof the moleculardockingof VEB were consistentwith its GL-inhibitoryactivity.It can concludethat the crudeethanolextractand fractionsshow inhibitoryactivityagainstthe GL enzyme.pt_BR
dc.identifier.citationRUAS, N. R. et al. Inhibition of α-Glycosidase by Lippia dulcis Trevir. (Verbenaceae) preparations, quantification of verbascoside, and study of its molecular docking. Chemistry & Biodiversity, [S.l.], v. 20, n. 2, Feb. 2023.pt_BR
dc.identifier.urihttps://repositorio.ufla.br/handle/1/56695
dc.identifier.urihttps://onlinelibrary.wiley.com/doi/10.1002/cbdv.202200760pt_BR
dc.languageen_USpt_BR
dc.publisherWileypt_BR
dc.rightsrestrictAccesspt_BR
dc.sourceChemistry & Biodiversitypt_BR
dc.subjectMedicinal plantpt_BR
dc.subjectCapim docept_BR
dc.subjectHypoglycemic agentpt_BR
dc.subjectGlucosidase inhibitorspt_BR
dc.subjectPhenylethanoid glycosidept_BR
dc.titleInhibition of α-Glycosidase by Lippia dulcis Trevir. (Verbenaceae) preparations, quantification of verbascoside, and study of its molecular dockingpt_BR
dc.typeArtigopt_BR

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