Sarcoma de sítio de aplicação em felinos

Abstract

Injection-site sarcomas are malignant neoplasms whose mesenchymal origin is characterized by aggressive biological behavior, developing from various tissues, being fibrosarcoma the most common histological type in felines. Despite wide research, the pathogenesis of the disease is still not fully understood, the most accepted hypothesis suggests that administration of vaccines, medications and other injectables into the subcutaneous or intramuscular tissue of predisposed cats may induce a chronic inflammatory reaction and, subsequently, neoplastic transformation. Related to epidemiology, it presents low prevalence and high rates of regress even after aggressive treatments. The diagnosis is performed through biopsy and histopathological examination, assessment of the extent of the primary tumor, the standard staging and general evaluation of the health of these patients. The multimodal therapeutic approach, associating radical surgical excision with radiotherapy, chemotherapy or immunotherapy, has shown better results. Choosing the injection site, frequency of vaccination and recommendations to reduce the inflammatory reaction are important considerations for prevention. The aim of this review is to provide an overview of the current knowledge on feline application site sarcoma.