Plausible mechanisms of Niclosamide as an antiviral agent against COVID-19

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dc.creatorPindiprolu, Sai Kiran S. S.
dc.creatorPindiprolu, Sai Harshini
dc.date.accessioned2020-05-26T15:57:43Z
dc.date.available2020-05-26T15:57:43Z
dc.date.issued2020-07
dc.description.abstractCorona virus disease 2019 (COVID-19) pandemic caused 18 440 deaths world wide as of 25 March 2020 and posing a serious threat to public health. There is a need, therefore, for effective therapeutic strategies to cure this disease. However, high attrition rates, substantial costs and slow pace are the major limitations of novel drug discovery. Drug repurposing, by employing ‘old’ drugs to treat ‘new’ diseases is an attractive approach in drug discovery. Niclosamide (NIC) is an approved anti-helminthic drug with diverse antiviral mechanisms. In this work we hypothesize, the potential antiviral mechanisms of NIC against COVID-19.pt_BR
dc.identifier.citationPINDIPROLU, S. K. S. S.; PINDIPROLU, S. H. Plausible mechanisms of Niclosamide as an antiviral agent against COVID-19. Medical Hypotheses, [S.l.], v. 140, July 2020.pt_BR
dc.identifier.urihttps://repositorio.ufla.br/handle/1/41236
dc.identifier.urihttp://www.sciencedirect.com/science/article/pii/S0306987720305892pt_BR
dc.languageen_USpt_BR
dc.publisherElsevierpt_BR
dc.rightsopenAccesspt_BR
dc.sourceMedical Hypothesespt_BR
dc.subjectCOVID-19pt_BR
dc.subjectSevere Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2)pt_BR
dc.subjectDrug discoverypt_BR
dc.subjectRepurposingpt_BR
dc.subjectNiclosamidept_BR
dc.titlePlausible mechanisms of Niclosamide as an antiviral agent against COVID-19pt_BR
dc.typeArtigopt_BR

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FCS - Artigos sobre Coronavirus Disease 2019 (COVID-19)