The spike glycoprotein of the new coronavirus 2019-nCoV contains a furin-like cleavage site absent in CoV of the same clade

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dc.creatorCoutard, B.
dc.creatorValle, C.
dc.creatorLamballerie, X. de
dc.creatorCanard, B.
dc.creatorSeidah, N. G.
dc.creatorDecroly, E.
dc.date.accessioned2020-05-05T20:43:47Z
dc.date.available2020-05-05T20:43:47Z
dc.date.issued2020-04
dc.description.abstractIn 2019, a new coronavirus (2019-nCoV) infecting Humans has emerged in Wuhan, China. Its genome has been sequenced and the genomic information promptly released. Despite a high similarity with the genome sequence of SARS-CoV and SARS-like CoVs, we identified a peculiar furin-like cleavage site in the Spike protein of the 2019-nCoV, lacking in the other SARS-like CoVs. In this article, we discuss the possible functional consequences of this cleavage site in the viral cycle, pathogenicity and its potential implication in the development of antivirals.pt_BR
dc.identifier.citationCOUTARD, B. et al. The spike glycoprotein of the new coronavirus 2019-nCoV contains a furin-like cleavage site absent in CoV of the same clade. Antiviral Research, [S.l.], v. 176, Apr. 2020.pt_BR
dc.identifier.urihttps://repositorio.ufla.br/handle/1/40605
dc.identifier.urihttp://www.sciencedirect.com/science/article/pii/S0166354220300528pt_BR
dc.languageen_USpt_BR
dc.publisherElsevierpt_BR
dc.rightsopenAccesspt_BR
dc.sourceAntiviral Researchpt_BR
dc.subject2019-nCoVpt_BR
dc.subjectSevere Acute Respiratory Syndrome Coronavirus (SARS-CoV)pt_BR
dc.subjectSpike proteinpt_BR
dc.subjectMaturation proteasept_BR
dc.subjectFurinpt_BR
dc.subjectAntiviralspt_BR
dc.titleThe spike glycoprotein of the new coronavirus 2019-nCoV contains a furin-like cleavage site absent in CoV of the same cladept_BR
dc.typeArtigopt_BR

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FCS - Artigos sobre Coronavirus Disease 2019 (COVID-19)