Peroxoniobium inhibits leukemia cell growth

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dc.creatorPereira-Maia, Elene C.
dc.creatorSouza, Ivina P.
dc.creatorNunes, Kelen J. R. C.
dc.creatorCastro, Alexandre A.
dc.creatorRamalho, Teodorico C.
dc.creatorSteffler, Fernando
dc.creatorDuarte, Helio A.
dc.creatorPacheli, Ana
dc.creatorChagas, Poliana
dc.creatorOliveira, Luiz C. A.
dc.date.accessioned2019-07-16T11:50:53Z
dc.date.available2019-07-16T11:50:53Z
dc.date.issued2018
dc.description.abstractA new class of polyoxoniobate complex has been synthesized and characterized as a novel anticancer agent for photodynamic therapy. The complex inhibits the growth of chronic myelogenous leukemia cells with an IC50 value of 30 μM, in the dark. However, upon exposure to light (365 nm) there is a fivefold increase in the cytotoxic activity. Light radiation activate the complex with the formation of radical species capable of interacting with DNA according to our experimental and theoretical data.pt_BR
dc.identifier.citationPEREIRA-MAIA, E. C. et al. Peroxoniobium inhibits leukemia cell growth. RSC Advances, [S.l.], v. 8, n. 19, p. 10310-10313, 2018. DOI: 10.1039/c8ra00898a.pt_BR
dc.identifier.urihttps://repositorio.ufla.br/handle/1/35319
dc.languageen_USpt_BR
dc.publisherRoyal Society of Chemistry (RSC)pt_BR
dc.rightsacesso abertopt_BR
dc.rights.urihttp://creativecommons.org/licenses/by-nc/4.0/*
dc.rights.urihttp://creativecommons.org/licenses/by-nc/4.0/
dc.sourceRSC Advancespt_BR
dc.subjectPolyoxoniobate complexpt_BR
dc.subjectAnticancer agentpt_BR
dc.subjectPhotodynamic therapypt_BR
dc.titlePeroxoniobium inhibits leukemia cell growthpt_BR
dc.typeArtigopt_BR

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