New In Silico insights into the application of (Hydroxy)Chloroquine with Macrolide Antibiotic Co-Crystals against the SARS-CoV-2 Virus

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dc.creatorCastro, Alexandre A. de
dc.creatorAssis, Letícia C.
dc.creatorCunha, Elaine F. F. da
dc.creatorRamalho, Teodorico C.
dc.creatorLa Porta, Felipe A.
dc.date.accessioned2022-08-05T18:31:37Z
dc.date.available2022-08-05T18:31:37Z
dc.date.issued2022
dc.description.abstractIn this in silico study, different pharmaceutical co-crystals based on (hydroxy)chloroquine with macrolide antibiotics (azithromycin, clarithromycin, or erythromycin A) were analyzed for the first time. These findings present a new molecular perspective and therefore suggest that the combination of (hydroxy)chloroquine/azithromycin, in the stoichiometric ratio of 1:1, as model co-crystal systems has less toxicity and is the most effective for inhibiting the new severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).pt_BR
dc.identifier.citationCASTRO, A. A. de et al. New In Silico insights into the application of (Hydroxy)Chloroquine with Macrolide Antibiotic Co-Crystals against the SARS-CoV-2 Virus. Covid, [S. l.], v. 2, n. 3, p. 230-243, 2022. DOI: 10.3390/covid2030018.pt_BR
dc.identifier.urihttps://repositorio.ufla.br/handle/1/50852
dc.languageen_USpt_BR
dc.publisherMDPIpt_BR
dc.rightsAttribution 4.0 International*
dc.rightsAttribution 4.0 International
dc.rightsacesso abertopt_BR
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.sourceCovidpt_BR
dc.subject(hydroxy)chloroquinept_BR
dc.subjectMacrolide antibioticspt_BR
dc.subjectCo-crystalspt_BR
dc.subjectSARS-CoV-2pt_BR
dc.subjectMolecular modellingpt_BR
dc.subjectHidroxicloroquinapt_BR
dc.subjectAntibióticos macrolídeospt_BR
dc.subjectCocristaispt_BR
dc.subjectModelagem molecularpt_BR
dc.titleNew In Silico insights into the application of (Hydroxy)Chloroquine with Macrolide Antibiotic Co-Crystals against the SARS-CoV-2 Viruspt_BR
dc.typeArtigopt_BR

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