Eficacia de florfenicol para el tratamiento de pioderma por Staphylococcus intermedius en perros

Abstract

The aim of this study was to evaluate the effect of florfenicol treatment at doses of10 and 20 mg/kg administered IM, in the treatment of canine pyoderma due toStaphylococcus intermedius, using pharmacokinetic/pharmacodynamic modelling (PK/PD). A Monte Carlo simulation of the pharmacokinetic and pharmacodynamic parameterswas performed, followed by a PK/PD modelling to determine the efficacy rates in thetreatment of bacterial infection, according to the minimum inhibitory concentration (MIC)of S. intermedius, using the range between 0.25 and 2 μg/ml. The probabilities of obtainingthe bacteriological eradication index with the 10 mg/kg dose were 97, 77, 7 and 1%, andwith the 20 mg/kg dose it was 95, 87, 61 and 7%, according to bacterial MICs of 0.25, 0.5,1 and 2 μg/ml, respectively. The probability of obtaining a bacteriological cure aftertreatment with the 10 mg/kg dose decreased significantly for infections caused bymicroorganisms with MICs higher than 0.5 μg/ml (p<0.01), while for the 20 mg/kg dose kgwas with MIC greater than 1 μg/ml (p<0.01). The results show the need to incorporatebacteriological isolation, the determination of MIC and the optimization of therapeuticdoses based on bacterial susceptibility in the therapeutic protocol in order to avoidtherapeutic failures and, consequently, the increase in the development of microbialresistance.