Leishmanicidal activity of ibuprofen and its complexes with Ni(II), Mn(II) and Pd(II)

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dc.creatorCunha, Laís Cardoso
dc.creatorLage, Daniela Pagliara
dc.creatorFerreira, Lorena Sales
dc.creatorSaboia-Vahia, Leonardo
dc.creatorCoelho, Eduardo Antonio Ferraz
dc.creatorBelo, Vinícius Silva
dc.creatorTeixeira-Neto, Rafael Gonçalves
dc.creatorSoares, Luis Fernando
dc.creatorChagas, Rafael César Russo
dc.creatorSilva, Eduardo Sergio da
dc.date.accessioned2021-11-09T20:02:19Z
dc.date.available2021-11-09T20:02:19Z
dc.date.issued2020-03
dc.description.abstractLeishmaniases are neglected diseases that represent a significant public health concern in several countries. In this study, nickel (II), manganese (II), and palladium (II) coordination compounds with ibuprofen were synthesized, and their potential leishmanicidal activity was evaluated. The compounds were characterized by molar conductimetry, electronics spectroscopy, infrared vibrational spectroscopy, 13C NMR, and elemental analysis, and the data were compared with literature. Comparison of the leishmanicidal activity of these compounds against promastigotes of Leishmania amazonensis and the cytotoxicity against lung fibroblast cells indicated that the IbuNi (nickel ibuprofen complex) compound was promising because it had the highest selectivity index (3.28) compared to the other compounds. In vitro tests on infected macrophages were performed and showed a decrease in infectivity of 31.21% at the concentration of 184.75 μM for the above compound and indicated that IbuPd (palladium ibuprofen complex) was toxic.pt_BR
dc.identifier.citationCUNHA, L. C. et al. Leishmanicidal activity of ibuprofen and its complexes with Ni(II), Mn(II) and Pd(II). Inorganic Chemistry Communications, New York, v. 113, 107756, Mar. 2020. DOI: 10.1016/j.inoche.2019.107756.pt_BR
dc.identifier.urihttps://repositorio.ufla.br/handle/1/48456
dc.identifier.urihttps://doi.org/10.1016/j.inoche.2019.107756pt_BR
dc.languageen_USpt_BR
dc.publisherElsevierpt_BR
dc.rightsrestrictAccesspt_BR
dc.sourceInorganic Chemistry Communicationspt_BR
dc.subjectLeishmaniasispt_BR
dc.subjectCoordination compoundspt_BR
dc.subjectLeishmanicidal activitypt_BR
dc.subjectLeishmaniosept_BR
dc.subjectCompostos de coordenaçãopt_BR
dc.subjectAtividade leishmanicidapt_BR
dc.titleLeishmanicidal activity of ibuprofen and its complexes with Ni(II), Mn(II) and Pd(II)pt_BR
dc.typeArtigopt_BR

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