Identification of Two New Phosphorylated Polyketides from a Brazilian Streptomyces sp. Through the Use of LC–SPE/NMR

Abstract

Two new polyketide phosphate monoesters, phosdiecin A (1) and phosdiecin B (2), were isolated from a culture of the marine Streptomyces sp. SS99BA‐2 using the hyphenated technology LC–SPE/NMR. The compounds showed to be new representatives of an important class of antitumor antibiotic metabolites known as fostriecins. Their structures, including relative configuration attribution, were fully elucidated through extensive analyses of NMR and MALDI‐TOF/TOF HR‐MS data. Herein, the application of this system to isolate and identify the new compounds is described.