Is the anti-filarial drug diethylcarbamazine useful to treat COVID-19?

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dc.creatorAbeygunasekera, Anuruddha
dc.creatorJayasinghe, Saroj
dc.date.accessioned2020-06-22T19:30:20Z
dc.date.available2020-06-22T19:30:20Z
dc.date.issued2020-10
dc.description.abstractSARS-CoV-2 virus has resulted in a devastating pandemic of COVID-19. Exploring compounds that could offer a breakthrough in treatment is the need of the hour. Re-positioning cheap, freely available and safe drugs is a priority. The paper proposes evidence for the potential use of diethylcarbamazine (DEC) in the treatment of COVID-19. DEC has inhibitory effects on arachidonic acid metabolism to prostaglandins, little known anti-viral effects on animal retroviruses and demonstrated anti-inflammatory actions in animal models of lung inflammation indicating the need to explore this hypothesis further. We believe this is the first time DEC is being proposed to treat COVID-19.pt_BR
dc.identifier.citationABEYGUNASEKERA, A.; JAYASINGHE, S. Is the anti-filarial drug diethylcarbamazine useful to treat COVID-19? Medical Hypotheses, [S.l.], v. 143, Oct. 2020.pt_BR
dc.identifier.urihttps://repositorio.ufla.br/handle/1/41526
dc.identifier.urihttps://www.sciencedirect.com/science/article/pii/S0306987720305636pt_BR
dc.languageen_USpt_BR
dc.publisherElsevierpt_BR
dc.rightsopenAccesspt_BR
dc.sourceMedical Hypothesespt_BR
dc.subjectSevere Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2)pt_BR
dc.subjectCoronapt_BR
dc.subjectCOVID-19pt_BR
dc.subjectDiethylcarbamazine (DEC)pt_BR
dc.titleIs the anti-filarial drug diethylcarbamazine useful to treat COVID-19?pt_BR
dc.typeArtigopt_BR

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FCS - Artigos sobre Coronavirus Disease 2019 (COVID-19)