Please use this identifier to cite or link to this item: http://repositorio.ufla.br/jspui/handle/1/50580
Title: Suplementação de vitamina D por longo período demonstra efeito protetor contra a recidiva da Esclerose Múltipla: Revisão sistemática
Keywords: Esclerose multipla
Vitamina D
Sistema nervoso
Mielina
Multiple sclerosis
Vitamin D
Nervous system
Myelin
Issue Date: 2021
Publisher: Universidade Federal de São Paulo (Unifesp)
Citation: BATISTA, F. R.; SANTIAGO, A. F.; HORIQUINI-BARBOSA, E. Suplementação de vitamina D por longo período demonstra efeito protetor contra a recidiva da Esclerose Múltipla: Revisão sistemática. Revista Neurociências, [S.l.], v. 29, 2021.
Abstract: Introduction. Multiple Sclerosis (MS) is a demyelinating, inflammatory, chronic and degenerative disease of the central nervous system. The main hypotheses for the disease is the genetic predisposition associated with environmental factors, which originates the immunesystem dysfunction. Studies suggest a relationship between vitamin D deficiency and MS, and according to researchers, vitamin D has a role in preventing and decreasing the rates of disease recurrence. Treatment for MS is established by the use of immunosuppressants and immunomodulators and some studies demonstrate evidence of the immunomodulary effects of vitamin D, which stimulates T cell activation in patients with MS. Objective. In the present study, we address the possibility to discuss and investigate, through a systematic review, the effectiveness of vitamin D supplementation treatment in MS patients. Method. This study is a systematic review of the literature, carried out in the electronic databases PubMed, MedLine, Scielo and Lilacs, using the combination of specific terms. Results. The scientific search resulted in 219 studies, however, applying the inclusion and exclusion criteria, five articles were selected. Conclusion. This review demonstrated that vitamin D supplementation, used for long periods, increases the amount of the metabolically active form of vitamin D in plasma, and consequently acts as a protective factor against MS. However, further studies are needed to elucidate the protective mechanism of vitamin D.
URI: http://repositorio.ufla.br/jspui/handle/1/50580
Appears in Collections:DNU - Artigos publicados em periódicos



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