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http://repositorio.ufla.br/jspui/handle/1/50852| Título: | New In Silico insights into the application of (Hydroxy)Chloroquine with Macrolide Antibiotic Co-Crystals against the SARS-CoV-2 Virus |
| Palavras-chave: | (hydroxy)chloroquine Macrolide antibiotics Co-crystals SARS-CoV-2 Molecular modelling Hidroxicloroquina Antibióticos macrolídeos Cocristais Modelagem molecular |
| Data do documento: | 2022 |
| Editor: | MDPI |
| Citação: | CASTRO, A. A. de et al. New In Silico insights into the application of (Hydroxy)Chloroquine with Macrolide Antibiotic Co-Crystals against the SARS-CoV-2 Virus. Covid, [S. l.], v. 2, n. 3, p. 230-243, 2022. DOI: 10.3390/covid2030018. |
| Resumo: | In this in silico study, different pharmaceutical co-crystals based on (hydroxy)chloroquine with macrolide antibiotics (azithromycin, clarithromycin, or erythromycin A) were analyzed for the first time. These findings present a new molecular perspective and therefore suggest that the combination of (hydroxy)chloroquine/azithromycin, in the stoichiometric ratio of 1:1, as model co-crystal systems has less toxicity and is the most effective for inhibiting the new severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). |
| URI: | http://repositorio.ufla.br/jspui/handle/1/50852 |
| Aparece nas coleções: | DQI - Artigos publicados em periódicos |
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| Arquivo | Descrição | Tamanho | Formato | |
|---|---|---|---|---|
| ARTIGO_New In Silico insights into the application of (Hydroxy)Chloroquine with Macrolide Antibiotic Co-Crystals against the SARS-CoV-2 Virus.pdf | 3,85 MB | Adobe PDF | Visualizar/Abrir |
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