Use este identificador para citar ou linkar para este item: http://repositorio.ufla.br/jspui/handle/1/50852
Título: New In Silico insights into the application of (Hydroxy)Chloroquine with Macrolide Antibiotic Co-Crystals against the SARS-CoV-2 Virus
Palavras-chave: (hydroxy)chloroquine
Macrolide antibiotics
Co-crystals
SARS-CoV-2
Molecular modelling
Hidroxicloroquina
Antibióticos macrolídeos
Cocristais
Modelagem molecular
Data do documento: 2022
Editor: MDPI
Citação: CASTRO, A. A. de et al. New In Silico insights into the application of (Hydroxy)Chloroquine with Macrolide Antibiotic Co-Crystals against the SARS-CoV-2 Virus. Covid, [S. l.], v. 2, n. 3, p. 230-243, 2022. DOI: 10.3390/covid2030018.
Resumo: In this in silico study, different pharmaceutical co-crystals based on (hydroxy)chloroquine with macrolide antibiotics (azithromycin, clarithromycin, or erythromycin A) were analyzed for the first time. These findings present a new molecular perspective and therefore suggest that the combination of (hydroxy)chloroquine/azithromycin, in the stoichiometric ratio of 1:1, as model co-crystal systems has less toxicity and is the most effective for inhibiting the new severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).
URI: http://repositorio.ufla.br/jspui/handle/1/50852
Aparece nas coleções:DQI - Artigos publicados em periódicos



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