Use este identificador para citar ou linkar para este item: http://repositorio.ufla.br/jspui/handle/1/28403
Título : First evaluation of the antimutagenic effect of mangaba fruit in vivo and its phenolic profile identification
Autor: Lima, Juliana Pinto de
Azevedo, Luciana
Souza, Nádia Janaina de
Nunes, Elisangela Elena
Vilas Boas, Eduardo Valério de Barros
Palavras-chave: Mangaba - Antimutagenic effect
Mangaba - Phenolic profile identification
Mangaba - Efeito antimutagênico
Mangaba - Identificação do perfil fenólico
Publicador: Elsevier
Data da publicação: Set-2015
Referência: LIMA, J. P. de et al. First evaluation of the antimutagenic effect of mangaba fruit in vivo and its phenolic profile identification. Food Research International, Barking, v. 75, p. 216-224, Sept. 2015.
Abstract: The chemical composition and functional effects of mangaba fruit pulp were evaluated through a multi-endpoint assay in mice, consisting of the bone marrow micronucleus test, gut micronucleus test, and the apoptosis, oxidative stress, and comet assays. Mangaba fruit pulp was administered in three doses, 10, 20, and 40 ml/kg body weight (b.w.), by gavage to male Swiss mice against doxorubicin and dimethylhydrazine-induced mutagenicity. The phenolic profile of the mangaba fruit pulp was evaluated by HPLC, and seven compounds were identified: gallic acid, catechin, chlorogenic acid, vanillic acid, o-coumaric acid, rosmarinic acid, and rutin. The in vivo tests revealed that mangaba fruit pulp showed no toxic/mutagenic effects in any of the assays performed, and also showed protective effects at all endpoints. At the three administered extract concentrations, the main results about the protective effects were as follows: bone marrow micronucleus test (42.33, 58.14, and 77.21%), micronucleus gut test (34.21, 63.15, and 78.07%), and apoptosis index (57.5, 43.68, and 65.52%). This study provides scientific evidence for the antimutagenic potential of mangaba fruit pulp and emphasizes its potential as a functional food with widespread applicability in the food industry.
URI: https://www.sciencedirect.com/science/article/pii/S0963996915300338#!
http://repositorio.ufla.br/jspui/handle/1/28403
Idioma: en_US
Aparece nas coleções:DCA - Artigos publicados em periódicos

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