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metadata.artigo.dc.title: Global analysis of the MATE gene family of metabolite transporters in tomato
metadata.artigo.dc.creator: Santos, Adolfo Luís dos
Chaves-Silva, Samuel
Yang, Lina
Maia, Lucas Gontijo Silva
Chalfun-Júnior, Antonio
Sinharoy, Senjuti
Zhao, Jian
Benedito, Vagner Augusto
metadata.artigo.dc.subject: Antiporter
Genome evolution
Metabolic gene cluster
Regulatory gene network
metadata.artigo.dc.publisher: BioMed Central 30-Oct-2017
metadata.artigo.dc.identifier.citation: SANTOS, A. L. dos et al. Global analysis of the MATE gene family of metabolite transporters in tomato. BMC Plant Biology, [S.l.], v. 17, p. 1-13, Oct. 2017.
metadata.artigo.dc.description.abstract: Background Species in the Solanaceae family are known for producing plethora of specialized metabolites. In addition to biosynthesis pathways, a full comprehension of secondary metabolism must also take into account the transport and subcellular compartmentalization of substances. Here, we examined the MATE (Multidrug and Toxic Compound Extrusion, or Multi-Antimicrobial Extrusion) gene family in the tomato (Solanum lycopersicum) genome with the objective of better understanding the transport of secondary metabolites in this model species. MATE membrane effluxers encompass an ancient gene family of secondary transporters present in all kingdoms of life, but with a remarkable expansion in plants. They mediate the transport of primary and secondary metabolites using the proton motive force through several membrane systems of the cell. Results We identified 67 genes coding for MATE transporters in the tomato genome, 33 of which are expressed constitutively whereas 34 are expressed in specific cell types or environmental conditions. Synteny analyses revealed bona fide paralogs and Arabidopsis orthologs. Co-expression analysis between MATE and regulatory genes revealed 78 positive and 8 negative strong associations (ρ≥|0.8|). We found no evidence of MATE transporters belonging to known metabolic gene clusters in tomato. Conclusions Altogether, our expression data, phylogenetic analyses, and synteny study provide strong evidence of functional homologies between MATE genes of tomato and Arabidopsis thaliana. Our co-expression study revealed potential transcriptional regulators of MATE genes that warrant further investigation. This work sets the stage for genome-wide functional analyses of MATE transporters in tomato and other Solanaceae species of economic relevance.
metadata.artigo.dc.language: en_US
Appears in Collections:DBI - Artigos publicados em periódicos

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