Please use this identifier to cite or link to this item: http://repositorio.ufla.br/jspui/handle/1/32511
Title: Amperometric flow-injection determination of the anthelmintic drugs ivermectin and levamisole using electrochemically pretreated boron-doped diamond electrodes
Keywords: Ivermectin
Levamisole
Amperometric detection
Electrochemical pretreatment
Ivermectina
Detecção amperométrica
Pré-tratamento eletroquímico
Issue Date: Jan-2016
Publisher: Elsevier
Citation: LOURENCAO, B. C. et al. Amperometric flow-injection determination of the anthelmintic drugs ivermectin and levamisole using electrochemically pretreated boron-doped diamond electrodes. Sensors and Actuators B: Chemical, Lausanne, v. 222, p. 181-189, Jan. 2016.
Abstract: Sensitive, simple, low-cost, and rapid amperometric flow-injection methods were developed for determination of ivermectin (IVM) and levamisole (LVM) in anthelmintic pharmaceutical drugs and urine samples. These determinations were carried out with a cathodically (for IVM) or anodically (for LVM) pretreated boron-doped diamond electrode using aqueous 0.5 mol L−1 H2SO4 (with and without addition of 30% V/V of ethanol) as supporting electrolyte. The amperometric detection was performed at an applied electrode potential of E = 1.40 V, for IVM, and E = 1.90 V, for LVM, vs. Ag/AgCl (3.0 mol L−1 KCl). The respective analytical curves presented good linearity in the investigated concentration ranges (0.60–50 μmol L−1, for IVM, and 0.010–5.0 μmol L−1, for LVM) and the detection limits were 0.30 μmol L−1 for IVM, and 1 nmol L−1, for LVM. Investigation of possible interferents showed no significant interference with the here-proposed methods; thus, they were used to determine IVM and LVM in pharmaceutical formulations as well as in urine samples, with results that showed good agreement with comparative methods. Furthermore, a mechanism for LVM electrooxidation was proposed using exhaustive potentiostatic electrolysis and NMR measurements.
URI: https://www.sciencedirect.com/science/article/pii/S0925400515302148#!
http://repositorio.ufla.br/jspui/handle/1/32511
Appears in Collections:DQI - Artigos publicados em periódicos

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