Use este identificador para citar ou linkar para este item: http://repositorio.ufla.br/jspui/handle/1/48806
Título: Eucalyptus grandis and Eucalyptus microcorys essential oils: in vitro modulation of hemostasis and genotoxic activity
Palavras-chave: 1,8-cineole
Snake venom proteases
Comet assay
Chemical characterization
Enzyme inhibitors
Hemostasis
Data do documento: 2021
Editor: Wiley
Citação: ESPOSITO, M. A. et al. Eucalyptus grandis and Eucalyptus microcorys essential oils: in vitro modulation of hemostasis and genotoxic activity. Brazilian Archives of Biology and Technology, [S.l.], v. 64, p. 1-10, 2021. DOI: 10.1590/1678-4324-2021210109.
Resumo: The genus Eucalyptus present high content of essential oil (EO). This study evaluated the pharmacological properties of Eucalyptus grandis (EG) and Eucalyptus microcorys (EM) EOs. The major component in both EOs was 1,8-Cineole. Both essential oils prevented thrombus dissolution and reduced clotting, hemolysis, and genotoxicity induced by snake venoms. 50% (EM) and 73% (EG) were the greatest inhibitions obtained in the thrombolytic assay - thrombolysis induced by B. moojeni venom. Increases in clotting time were also observed, with values considered significant between 10-27 seconds. Lysis values 50% lower than the negative control were observed in both EOs. The EOs also protected fibrinogenolysis induced by snake venom. EM EO was more effective in reducing venom-induced DNA fragmentation in the comet assay, with arbitrary unit values 66.15% lower than the positive control. These oils present wide application potential considering the pharmacological properties observed in this study.
URI: http://repositorio.ufla.br/jspui/handle/1/48806
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