Importância das vacinas sintéticas contra o carrapato Rhipicephalus microplus

Abstract

Rhipicephalus microplus, from an economic standpoint, is the most important parasite of cattle herds in Central and South America and Australia, it causes severe direct and indirect losses in animal production. Control of this parasite rests primarily on the use of acaricides drugs that are responsible for the selection of resistant of populations and cause contamination with residues in meat, dairy products and in the environment. This creates a need to the development of alternative, safe and efficient control, which may act in an integrated manner. Advances in molecular biology techniques have driven several lines of research in veterinary parasitology, particularly in vaccine development. Vaccines derived from the intestinal glycoprotein of R. microplus, the Bm86, have broad potential as a non-chemical control of ticks. The synthetic peptide SBm7462®, a synthetic vaccine derivative of the Bm86, has demonstrated its effectiveness in inducing the immune response of animals immunized with it.