Simulação do efeito antinociceptivo de detomidina em cavalos

Abstract

This study aimed to simulate the antinociceptive effect of detomidine IV and IM in horses at a dose of 80 ug / kg. The pharmacokinetic / pharmacodynamic analysis was performed using the equation. Pharmacokinetic and pharmacodynamic data were those corresponding to the study at doses of 30æg / kg. The antinociceptive effect was considered from the nociceptive threshold changes. Finally, the antinociceptive effect was determined from the high doses of detomidine (80 ug / kg) from the plasma concentrations by means of a simulation. The simulated antinociceptive effect from plasma concentrations corresponding to doses of 80 ug / kg was 90%, 80% and 40% up to 120, 180 and 240 minutes for the IM route and was 90%, 80% and 60% up to 120, 180 and 240 minutes for the IV route, respectively. Elevated doses of detomidine determine superior and more gilding effects at doses of 30æg / kg by respective routes of administration. However, in vivo studies complete at these high doses are required to verify adverse effects.