Avaliação da atividade proliferativa e inibitória de extratos e frações de microrganismos marinhos sobre células MCF-7

Abstract

Marine microorganisms have attracted the interest of researchers in various parts of the world because they represent a different source of secondary metabolites, due to environmental conditions that these organisms are subject. Marine organisms represent a rich source of structurally diverse molecules, however the use of this source for research of bioactive compounds has been little explored. This work aims to isolate strains of fungi and actinomycetes extracted from the ocean in South China to evaluate the productive potential of bioactive compounds. For this, we isolated 5,000 strains grown in liquid culture medium and 36 extracts obtained with different organic solvents. These extracts were evaluated by testing the biological activity (screening) with cancer cells (MCF - 7). Among all microorganisms investigated in this study under the MCF - 7 cells, the MS122 (R) A26 and actinomycetes ( Streptomyces sp.) showed respectively, to exert proliferative activity and cytotoxicity. The identification of proliferative activity with MS122 (R) contributes directly to support advances in studies on toxins associated to the development and growth of cancer cells. Further, the identification of cytotoxic activity with the A26 directly contributes to the discovery of new drugs inhibiting the growth of MCF - 7 cells.