Susceptibilidade de leveduras isoladas de mastite bovina a antimicrobianos

Abstract

Bovine mastitis is one of the most prevalent and impacting diseases in dairy farming worldwide. The disease is considered to have multifactorial nature and is caused by different microorganisms. Among these organisms, yeasts are uncommon agents but they can be considered emerging agents by several researchers. Considering the growing importance that these agents have in the etiology of mastitis in herds, it is of great importance to determine their susceptibility profile against to antimicrobials, seeking to deepen the knowledge related to epidemiology of mastitis caused by these agents and of new alternatives for its treatment and control. In the present study, 56 yeasts strains isolated from cases of mastitis in cattle herds from Minas Gerais were evaluated for antimicrobial susceptibility profiles, using the minimal inhibitory concentration (MIC) technique. The isolates were tested against amphotericin B, fluconazole, 5-FC flucytosine, itraconazole, miconazole, natamycin, posaconazole, ravuconazole and voriconazole. High levels of resistance and multidrug resistance were observed for antimicrobials in the studied population. The overall resistance rates observed were: amphotericin B (89.28%), itraconazole (76.78%), ravuconazole (67.85%), fluconazole (51.78%), posaconazole (41.07%), fluocytocin (37.5%) and voriconazole (28.57%), and. It was found that 21.42% of the isolates were multidrug-resistant. The study points to the need for permanent monitoring of resistance among mycotic agents that cause mastitis, to mitigate the problem of resistance and its implications to public health.