Uma metodologia para identificação de módulos formadores de sequências de proteínas mosaicas do trypanosoma cruzi a partir do transcriptoma do parasito utilizando a ferramenta blast

Abstract

This paper proposed a methodology for the identifying component modules of nucleotide sequences that code Trypanosoma cruzi mosaic proteins using BLAST. For the development of the methodology, MASP protein family was used and a set of default BLAST parameter values was initially applied. Afterwards, different combinations of parameter values were studied for result comparison, including those indicated in literature. The developed methodology proved to be efficient for the proposed objective, obtaining better results when non-default parameter values for low complexity region filter, E-value and initial word size were applied.