Integração PK/PD na medicina veterinária: determinação de doses intramuscular de cloxacilina sódica para infecções causadas por Staphylococcus spp em caprinos

Abstract

Pharmacokinetic/pharmacodynamic (PK/PD) modeling is used in the drug development process to select dosage regimens for use in clinical trials. This approach is an interactive process that brings together in vitro and in vivo experiments, population PK models, and in silico simulations to determine/optimize dosing regimens. With the emergence of antimicrobial resistance (AMR), this tool has also been used to optimize dose regimens for drugs available on the market. In Brazil, this strategy of adjusting dosage regimens for drugs available on the market has not yet been adopted in veterinary medicine. Thus, this study aims to elucidate aspects of PK/PD modeling in the selection and optimization of dosage regimens for antimicrobial in Veterinary Medicine and to present our study, which used PK/PD integration to define therapeutic protocols of cloxacillin sodium for systemic treatment of infections by Staphylococcus spp. in goats. This research group is the first to work with pharmacometrics in veterinary medicine in Brazil, and this is one of the first works in veterinary with this methodology in the country.