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Título : | A pneumonia outbreak associated with a new coronavirus of probable bat origin |
Autor: | Zhou, Peng Yang, Xing-Lou Wang, Xian-Guang Hu, Ben Zhang, Lei Zhang, Wei Si, Hao-Rui Zhu, Yan Li, Bei Huang, Chao-Lin Chen, Hui-Dong Chen, Jing Luo, Yun Guo, Hua Jiang, Ren-Di Liu, Mei-Qin Chen, Ying Shen, Xu-Rui Wang, Xi Zheng, Xiao-Shuang Zhao, Kai Chen, Quan-Jiao Deng, Fei Liu, Lin-Lin Yan, Bing Zhan, Fa-Xian Wang, Yan-Yi Xiao, Geng-Fu Shi, Zheng-Li |
Palavras-chave: | Coronavirus Severe acute respiratory syndrome Pathogenic virus Síndrome respiratória aguda grave Vírus patogênicos |
Publicador: | Springer Nature |
Data da publicação: | 2020 |
Referência: | ZHOU, P. et al. A pneumonia outbreak associated with a new coronavirus of probable bat origin. Nature, London, v. 579, p. 270-273, 2020. |
Abstract: | Since the outbreak of severe acute respiratory syndrome (SARS) 18 years ago, a large number of SARS-related coronaviruses (SARSr-CoVs) have been discovered in their natural reservoir host, bats1,2,3,4. Previous studies have shown that some bat SARSr-CoVs have the potential to infect humans5,6,7. Here we report the identification and characterization of a new coronavirus (2019-nCoV), which caused an epidemic of acute respiratory syndrome in humans in Wuhan, China. The epidemic, which started on 12 December 2019, had caused 2,794 laboratory-confirmed infections including 80 deaths by 26 January 2020. Full-length genome sequences were obtained from five patients at an early stage of the outbreak. The sequences are almost identical and share 79.6% sequence identity to SARS-CoV. Furthermore, we show that 2019-nCoV is 96% identical at the whole-genome level to a bat coronavirus. Pairwise protein sequence analysis of seven conserved non-structural proteins domains show that this virus belongs to the species of SARSr-CoV. In addition, 2019-nCoV virus isolated from the bronchoalveolar lavage fluid of a critically ill patient could be neutralized by sera from several patients. Notably, we confirmed that 2019-nCoV uses the same cell entry receptor—angiotensin converting enzyme II (ACE2)—as SARS-CoV. |
URI: | http://repositorio.ufla.br/jspui/handle/1/39411 |
Idioma: | en_US |
Aparece nas coleções: | FCS - Artigos sobre Coronavirus Disease 2019 (COVID-19) |
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ARTIGO_A pneumonia outbreak associated with a new coronavirus of probable bat origin.pdf | 10,61 MB | Adobe PDF | Visualizar/Abrir |
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